Professional Resources
Access specialised educational resources and guides developed by our clinical team to support your understanding of pain conditions and personalised care pathways.
Series I of II: General Pathways of Pain Sensation
The book delves into the intricate mechanisms of pain processing within the central and peripheral nervous systems. It explores how nociceptive signals are transmitted, modulated, and interpreted, highlighting the roles of various neurotransmitters and receptors in enhancing pain sensations.
Series II of II: Pharmacological Targeting of Pain Pathways
The present manuscript constitutes the second in this series and transitions from mechanistic description to pharmacological interrogation. Its purpose is to map the complete inventory of analgesic agents currently approved by the Therapeutic Goods Administration (TGA) and available within the Australian health system onto the specific pathway loci, receptor classes, ion channel subtypes, and second-messenger cascades delineated in the first paper.
Cytokine and Chemokine Immunopathology in Complex Regional Pain Syndrome
This paper provides a comprehensive synthesis of the cytokine and chemokine immunopathology of CRPS, identifying for each mediator its cellular origin, principal target sites, available Australian diagnostic blood tests, and the TGA-listed or accessible pharmacological agents capable of attenuating its activity
Dysautonomia as a Systems-Level Driver of Persistent Pain: An Integrative Mechanistic Synthesis
This paper reviews the accumulating evidence from physiology, immunology, and clinical research on the concept of autonomic dysregulation as the systemic generator of pain. In addition to elucidating brainstem modulatory architecture, baroreflex and vagal afferent signalling, the cholinergic anti-inflammatory pathway, HPA corticoneural axis, and limbic interoceptive learning mechanisms, the paper synthesizes a comprehensive framework of pain pathophysiology.